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KMID : 0356219930240010030
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Journal of the Korean Military Medical Association
1993 Volume.24 No. 1 p.30 ~ p.39
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Effect of Acute Hypobaric-Hypoxia on the Defense Mechanisms against Oxygen Toxicity in Rat Heart
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Abstract
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Thepossibility that acute hypobaric-hypoxia alters the defense mechanisms against oxygen toxicity in rat heart has been investigated. Four different degrees of acute hypobaric-hypoxia were induced in vivo by hypobari
c chamber flight for 2 hours
at
15,000 feet, 20,000 feet and 30,000 feet, At the end of the each altitude exposure, the changes in serum ATP, lactate and glucose were determined. And the productions of superoxide radial and malondialdehyde(MDA), and the activities of total
superoxide
dismutase(total SOD), glutathione peroxidase(GSH-Px) and total ATPase in heart homogenate have been determined.
Both serum and tissue ATP, and glucose were decreased according to altitude. And serum and tissue lactate were increased according to altitude. Acute hypobaric-enhanced the productions of superoxide radical and MDA in heart homogenate as much as
125.8%and 246.9% than normal value, respectively, when altitudes ranged from 15,000 to 30,000 feet, Also the activities of total SOD, GSH-Px and total ATPase in heart homogenate showed 29.7%, 22.1% and 21.5% inhibitions compared with normal value
at
30,000 feet, respectively.
These results suggest that high levels of superoxide radical and peroxidized lipid resulting from inhibited superoxide dismutase and glutathione peroxidase may play a role in acute hypobaric-hypoxia induced heart damage.
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